Environmental Risks Monitoring of Shipwrecks in Italian Seas

After a description of the international regulatory framework, this paper examines the European project DE.E.P.P. and provides an overview of shipwreck databases in Italy. Afterwards, it reconstructs the recent history of the supertanker VLCC Haven which represents one of the largest Mediterranean shipwrecks. The findings of this paper emphasize the need to unify all the various agencies databases into a national Territorial Information System of potentially polluting wrecks. This System would be completed by all the information available in archives and press, to allow an adequate environmental risk monitoring and classification of shipwrecks in the Italian seas

Environmental Risks Monitoring of Shipwrecks in Italian Seas

After a description of the international regulatory framework, this paper examines the European project DE.E.P.P. and provides an overview of shipwreck databases in Italy. Afterwards, it reconstructs the recent history of the supertanker VLCC Haven which represents one of the largest Mediterranean shipwrecks. The findings of this paper emphasize the need to unify all the various agencies databases into a national Territorial Information System of potentially polluting wrecks. This System would be completed by all the information available in archives and press, to allow an adequate environmental risk monitoring and classification of shipwrecks in the Italian seas.Tras una descripción de la estructura regulatoria internacional, este artículo estudia el proyecto europeo DE.E.P.P. (Development of European guidelines for Potentially Polluting shipwrecks) y proporciona une vision de conjunto de las bases de datos de restos de naufragios en Italia. Posteriormente, reconstruye la historia reciente del superpetrolero VLCC Haven, que representa uno de los mayores restos de naufragios del Mediterráneo. Las conclusiones de este artículo destacan la necesidad de unificar las bases de datos de todas las diferentes agencias en un Sistema de Información Territorial nacional de restos potencialmente contaminantes. Este Sistema sería completado con toda la información disponible en los archivos y en la prensa, para permitir un control adecuado de los riesgos ambientales y la clasificación de los restos de naufragios en los mares Italianos.Après la description du cadre réglementaire international, cet article examine le Projet européen DE.E.P.P. (DEvelopment of European guidelines for Potentially Polluting shipwrecks) et fournit une vue d’ensemble des bases de données en matière d’échouement en Italie. Il reconstitue ensuite l’histoire récente du superpétrolier VLCC Haven, l’un des plus importants échouements ayant eu lieu en Méditerranée. Les conclusions de cet article soulignent la nécessité de réunir toutes les bases de données des diverses agences en un Système territorial d’informations sur les échouements potentiellement polluants. Ce système serait complété par l’ensemble des informations disponibles dans les archives et la presse afin de permettre une gestion appropriée des risques environnementaux et la classification des échouements dans les eaux italiennes

Synthesis of enantiopure 2-amino-1-phenyl and 2-amino-2-phenyl ethanols using enantioselective enzymatic epoxidation and regio- and diastereoselective chemical aminolysis

\u2022 Several enantiopure 1,2-amino alcs. have been prepd. by combining a stereoselective enzymic epoxidn. of styrenes with regio- and stereoselective chem. reactions. An interesting reactivity has been noted concerning the ring opening of epoxides with NH3 under microwave activation

Independent and incremental prognostic value of increased left ventricular mass and reduced relative wall thickness in patients with chronic systolic heart failure and left ventricular remodeling

Independent and incremental prognostic value of increased left ventricular mass and reduced relative wall thickness in patients with chronic systolic heart failure and left ventricular remodelin

Synthesis and Biological Evaluation of 1,4-Diaryl-2-azetidinones as Specific Anticancer Agents: Activation of Adenosine Monophosphate Activated Protein Kinase and Induction of Apoptosis

A series of novel 1,4-diaryl-2-azetidinones were synthesized and evaluated for antiproliferative activity, cell cycle effects, and apoptosis induction. Strong cytotoxicity was observed with the best compounds (±)-<i>trans</i>-<b>20</b>, (±)-<i>trans</i>-<b>21</b>, and enantiomers (+)-<i>trans</i>-<b>20</b> and (+)-<i>trans</i>-<b>21</b>, which exhibited IC₅₀ values of 3–13 nM against duodenal adenocarcinoma cells. They induced inhibition of tubulin polymerization and subsequent G2/M arrest. This effect was accompanied by activation of AMP-activated protein kinase (AMPK), activation of caspase-3, and induction of apoptosis. Additionally, the most potent compounds displayed antiproliferative activity against different colon cancer cell lines, opening the route to a new class of potential therapeutic agents against colon cancer